PRACE is welcoming project proposals requesting computing resources to contribute to the mitigation of the impact of the COVID-19 pandemic. This applies, without being exhaustive, to the following topics:
- Biomolecular research to understand the mechanisms of the virus infection
- Bioinformatics research to understand mutations, evolution, etc.
- Bio-simulations to develop therapeutics and/or vaccines
- Epidemiologic analysis to understand and forecast the spread of the disease
- Other analyses to understand and mitigate the impact of the pandemic
This call for proposals will follow a fast track review process to provide swift feedback to the applicants.
This call is open until further notice. Applications are evaluated within one week and start as soon as possible, if awarded.
The fist project has already been awarded: Biomolecular research to understand the mechanisms of the virus infection/Bio-simulations to develop therapeutics
In the face of the growing pandemic caused by the retrovirus SARS-CoV-2 (Covid-19), there is an urgent need for inhibitors capable of selectively targeting some of its key proteins, but perhaps also key nucleic acid sequences in its genome. This project, which brings together a consortium of complementary teams, is based on several strengths:
- The recent provision of high-resolution structures of several Covid-19 proteins
- The availability of a new polarized molecular dynamics software, Tinker-HP, to achieve simulation quality that cannot be achieved with other software
- The ability to reprocess Tinker-HP trajectories through a set of screening and docking software to test new molecules active against Covid-19.